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First, it disrupts the process of melanin synthesis by inducing the release of high mobility group box 1 (HMGB1) protein, thus downregulating the melanin biosynthesis-related proteins: melanocyte-inducing transcription factor, tyrosinase, tyrosinase-related protein-1, tyrosinase-related protein-2, RAB27A and fascin actin-bundling protein 1 [17, 18]

An anthropometric survey of Korean hand and hand shape types

In the bile duct-ligated rats as well as in the occlusion-like syndrome and Budd-Chiarisyndrome rats [13,22,23,24,25], there was a consistent counteraction of the intracranial (superior sagittal sinus) hypertension, portal and caval hypertension, aortal hypotension, and congested veins (i.e., reflecting trapped volumecongested inferior caval vein and superior mesenteric vein)

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